Workshop

Non-equilibrium Physics of Self-Assembly: from Viruses to Nano-containers

13 - 17 Nov 2023

ICMS, Bayes Centre, Edinburgh

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Organiser

Rachel Bennett ,University of Bristol

Robijn Bruinsma ,University of California, Los Angeles

Buddhapriya Chakrabarti ,University of Sheffield

Tanniemola Liverpool ,University of Bristol

Reidun Twarock ,University of York

About

This interdisciplinary meeting brought together theoreticians and experimentalists working on viruses and protein nano-containers, to stimulate collaborations in the following areas:

1. Design principles of natural and artificial protein containers
2. Kinetics of protein container assembly
3. Cargo/genome packaging and release
4. Evolutionary optimisation of container geometry
5. Applications in virus nanotechnology

Programme

Meet the speakers

MONDAY 13 NOVEMBER 2023

Registration and Refreshments

Welcome and Housekeeping

William Gelbart

UCLA

IN CELLULO versus IN VITRO RECONSTITUTION OF RNA-SPECIFIC VIRUS-LIKE PARTICLES

Abstract

Dek Woolfson

University of Bristol

Rationally and computational design of functional protein barrels

Abstract

Farzad Fatehi

University of York

Geometry as a key to the virosphere – from viral infections to virus nanotechnology

Abstract

Refreshments

Abstract

Roya Zandi

University of CA, Riverside

The role of flexibility of capsid proteins in the symmetry of viral shells

Abstract

Danielle Tullman-Ercek

Northwestern University

Designing with nanoscale building blocks: engineering self-assembling protein superstructures for applications in vaccines, drug delivery and biochemical production

Abstract

Lunch

Abstract

David Bhella

MRC - University of Glasgow Centre for Virus Research

Capsid stability and receptor mediated priming in calicivirus entry

Slides

Alexander Borodavka

University of Cambridge

How do Viruses Use RNA Granules and RNA Chaperones to Assemble Their Segmented Genomes?

Abstract

Refreshments

Abstract

Uri Raviv

The Hebrew University of Jerusalem

Mechanism of Virus Capsid Assembly

Abstract

Erwin Frey

Ludwig-Maximilians-Universitaet Muenchen

The time complexity of self-assembly

Abstract

Welcome Reception, hosted at ICMS

Abstract

TUESDAY 14 NOVEMBER 2023

Seth Fraden

Brandeis University

Hierarchical assembly is more robust than egalitarian assembly in synthetic capsids

Abstract

Ard Louis

University of Oxford

Does self-assembly design have a built-in Occam's razor?

Abstract

Guillaume Tresset

Université Paris-Saclay

Antivirals alter the kinetic assembly pathway and elastic properties of Hepatitis B virus capsids

Abstract

(contributed) Paddy Royall

ESPCI Paris

Resolving Challenges in Self-Assembly with Nano Real Space Analysis

Abstract

Refreshments

Abstract

Carol Teschke

University of Connecticut

Using a scaffold to build a virus

Slides

Paul van der Schoot

Eindhoven University of Technology

Electrostatic Theory of the Acidity of the Solution in the Lumina of Viruses and Virus-Like Particles

Abstract

Lunch

Abstract

Michael Hagan

Brandeis University

Enhancing self-assembly with time-dependent protocols and liquid-liquid phase separation

Abstract

Jodi Hadden-Perilla

University of Delaware

Mechanistic insights into HBV capsid assembly and its inhibition revealed by all-atom MD simulations

Abstract

Refreshments

Abstract

Richard Bingham

University of York

Virus-like particles, packaging signals and assembly pathways.

Abstract

David Wales

Cambridge University

Energy landscapes for Self-Assembly

Abstract

Poster session

Abstract

WEDNESDAY 15 NOVEMBER 2023

Ulrich Schwarz

Heidelberg University

Competition between efficiency and selectivity in container assembly

Abstract

Charlotte Uetrecht

CSSB, Hamburg & University of Siegen

Flying viruses - mass spectrometry meets X-rays

Slides

Eric Dykemann

University of York

Exploring the effects of non-equilibrium processes on virus assembly in vivo

Abstract

Refreshments

Abstract

Alan Rein

National Cancer Institute

Pathway and Thermodynamic Analysis of HIV-1 Immature Particle Assembly

Abstract

Juan Perilla

University of Delaware

The Hiv-1 Capsid Mechanoelastic Properties Regulate Nuclear Import And Uncoating.

Abstract

Lunch

Abstract

Shenshen Wang

University of California, Los Angeles

Non-equilibrium physics of antigen recognition

Abstract

(contributed) Jure Dobnikar

Chinese Academy of Sciences

Self-assembly of viral capsids and packing of genome

Abstract

Refreshments

Abstract

Orlando Guzman

Universidad Autonoma Metropolitana - Iztapalapa (Online)

Kinetic model of high packaging selectivity of the dimeric HIV-1 genomic RNA

Abstract

Rees Garmann

San Diego State University

Capsid assembly and genome packaging in a simple plus-strand RNA virus

Abstract

(contributed) Sam Clark

University of York

Recoding mRNA therapeutic cargoes for efficient viral packaging

Abstract

Wouter Roos

Rijksuniversiteit Groningen

Single-molecule approaches to study viral self-assembly in real-time

Abstract

THURSDAY 16 NOVEMBER 2023

Don Hilvert

ETH Zürich

Evolving virus-like assemblies in the lab

Abstract

Jonathan Heddle

University of Durham

Towards dynamic artificial protein containers

Abstract

Joe Grove

MRC-University of Glasgow Centre for Virus Research

Using machine learning to map form and function across the virome

Abstract

(contributed) Andrew Shevchuk

Imperial College London

Direct label-free visualisation of virus particle assembly

Abstract

Refreshments

Abstract

Ed Hutchinson

MRC-University of Glasgow Centre for Virus Research

Bags, not boxes: integrative modelling of enveloped viruses

Abstract

(contributed) Alex Evilevitch

Lund University

Temperature-induced DNA density transition in phage lambda capsid revealed with contrast matching SANS

Abstract

Lunch

Abstract

Marco Vignuzzi

A*STAR ID Labs

Experimental evolution to uncover biological functions, essential genomic sequences, intramolecular partners and virus-host interactions.

Abstract

(contributed) Connie Chang

Mayo Clinic

Single cell virology using drop-based microfluidics

Abstract

Refreshments

Abstract

Jennifer McManus

University of Bristol

Rational design of protein phase transitions- equilibrium and non-equilibrium

(contributed) Rebecca Chandler-Bostock

University of Leeds

Genome-regulated Assembly of a ssRNA Virus May Also Prepare It for Infection

Abstract

Wilson Poon

University of Edinburgh

Disassembly of viruses

Abstract

Workshop Dinner, location tbc

Abstract

FRIDAY 17 NOVEMBER 2023

Tanniemola Liverpool

University of Bristol

Flexibility and defects in the soft self-assembly of synthetic biological systems

Abstract

Alena Khmelinskaia

Ludwig Maximilian University of Munich

Exploring the protein assembly space with structural flexibility

Abstract

Robijn Bruinsma

University of California

Genome Selection by RNA Viruses

Abstract

Bogdan Dragnea

Indiana University at Bloomington

The Bright Side of Small Icosahedral Virus-like Particles

Abstract

Packed lunch

Abstract

End of Workshop

Abstract