Societal and environmental challenges have lead to a surge in the interest and development of novel statistical tools to deal with large data sets and of efficient uncertainty quantification (UQ) methods for complex engineering applications. There were two main aims for this meeting. The first aim was to bring together key researchers from statistics and from applied mathematics working in spatial statistics and in UQ. The second aim was to go beyond the discussion and analysis of algorithms applied to toy problems and to instead focus on real large scale applications and on the scalability of novel statistical and UQ tools on modern supercomputers.